I think if DPC wants to go and off a main character and it's not having the same negative reception as Acting Lessons, that character can only be Quinn.
She is already a polarizing character inside and outside of the game and there are plenty of clues and signs that she is going down a road of no return right from the start. Getting on Vinny's bad side, getting on Buddy's bad side and now basically losing the only character that actually gave a fuck to her (Riona) and maybe even getting on Burke's bad side and eventually maybe even drawing attention from the Royces since her father basicaly killed their daughter. She is digging her grave faster as time passes.
I've called this waaaay back, that if MC is not on her route, Quinn can end up dead and this wouldn't surprise or make me angry. And I say this right now while I'm listening to 'Time to Rise', I absolutely love Quinn, even with all the shit she did with Rio and in the game, I can't drop her from my top 5 characters, it would take something bigger than what she has done yet for me to dislike her, but she indeed is journeying too deep into the darkness and I believe she won't find any light along the way when she is alone, she would find the deep end and rats down there.