What are your system specs? You may not meet minimums. My machine is running close to minimums, so I get weird graphical glitches.It's that screen, but I hit "Run anyway" and it still doesn't work.
Inside the game, there's another folder with another x64 executable.
I also start it, and it doesn't do anything.
I'll have to give up, because it doesn't solve the problem.
I also wouldn't bother with Windows Defender and get an actual virus scanner made by a serious company. I use TotalAV. Its great. Expensive, but great.
Some games have weird memory access issues, that most AVs ignore, but Windows Defender might not.